Resumo Este estudo objetivou avaliar a associação entre qualidade de vida e variáveis clínicas e sociodemográficas em pacientes diabéticos tipo 2, após iniciarem tratamento na Atenção Primária e Especializada. Trata-se de um estudo transversal analítico com amostra de pacientes diabéticos provenientes da Atenção Primária (n = 385) e Especializada (n = 385). A variável dependente, qualidade de vida, foi avaliada pelo Diabetes Quality of Life Measure – Brasil. Foram coletados dados clínicos e sociodemográficos. Análise bivariada pelo teste qui-quadrado testou a associação entre a variável dependente com as independentes. Em seguida, realizou-se análise de regressão logística múltipla. Na Atenção Especializada, os indivíduos que realizaram atividade física tiveram menos chance de ter pior qualidade de vida e aqueles com menor tempo de diagnóstico apresentaram mais chance de pior qualidade de vida. Na Atenção Primária, os que realizaram dieta e que apresentaram hemoglobina glicada ≤ 7% tiveram menos chance de ter pior qualidade de vida. Já os do sexo feminino apresentaram mais chance de pior qualidade de vida do que os do masculino. Conclui-se que com exceção do tempo de diagnóstico e sexo, as demais variáveis que influenciaram na qualidade de vida dos diabéticos foram fatores modificáveis.

Abstract This study aimed to assess the association between quality of life and clinical and sociodemographic variables in type 2 diabetes patients, after they had started treatment in Primary and Specialized Health Care. This is an analytical cross-sectional study with a sampling of diabetic patients from Primary (n = 385) and Specialized (n = 385) Health Care. The dependent variable, quality of life, was evaluated by the Diabetes Quality of Life Measure - Brazil. Clinical and sociodemographic data were collected. Bivariate analysis by chi square test tested the association between the dependent variable with the independent ones. Next, we performed an analysis of multiple logistic regression. In Specialized Health Care, individuals who practice physical activity had less chance of having worse quality of life and those with less time of diagnosis presented higher chance of worse quality of life. In Primary Health Care, those who performed diets and presented glycated hemoglobin ≤ 7% had less chance of having worse quality of life. Women presented higher chances of worse quality of life than men. We concluded that with exception to the time of diagnosis and sex, other variables that influenced quality of life of diabetics were modifiable factors (glycated hemoglobin, alimentary diet and physical activity).

Resumo Este estudo objetivou avaliar a associação entre qualidade de vida e variáveis clínicas e sociodemográficas em pacientes diabéticos tipo 2, após iniciarem tratamento na Atenção Primária e Especializada. Trata-se de um estudo transversal analítico com amostra de pacientes diabéticos provenientes da Atenção Primária (n = 385) e Especializada (n = 385). A variável dependente, qualidade de vida, foi avaliada pelo Diabetes Quality of Life Measure – Brasil. Foram coletados dados clínicos e sociodemográficos. Análise bivariada pelo teste qui-quadrado testou a associação entre a variável dependente com as independentes. Em seguida, realizou-se análise de regressão logística múltipla. Na Atenção Especializada, os indivíduos que realizaram atividade física tiveram menos chance de ter pior qualidade de vida e aqueles com menor tempo de diagnóstico apresentaram mais chance de pior qualidade de vida. Na Atenção Primária, os que realizaram dieta e que apresentaram hemoglobina glicada ≤ 7% tiveram menos chance de ter pior qualidade de vida. Já os do sexo feminino apresentaram mais chance de pior qualidade de vida do que os do masculino. Conclui-se que com exceção do tempo de diagnóstico e sexo, as demais variáveis que influenciaram na qualidade de vida dos diabéticos foram fatores modificáveis.

Abstract This study aimed to assess the association between quality of life and clinical and sociodemographic variables in type 2 diabetes patients, after they had started treatment in Primary and Specialized Health Care. This is an analytical cross-sectional study with a sampling of diabetic patients from Primary (n = 385) and Specialized (n = 385) Health Care. The dependent variable, quality of life, was evaluated by the Diabetes Quality of Life Measure - Brazil. Clinical and sociodemographic data were collected. Bivariate analysis by chi square test tested the association between the dependent variable with the independent ones. Next, we performed an analysis of multiple logistic regression. In Specialized Health Care, individuals who practice physical activity had less chance of having worse quality of life and those with less time of diagnosis presented higher chance of worse quality of life. In Primary Health Care, those who performed diets and presented glycated hemoglobin ≤ 7% had less chance of having worse quality of life. Women presented higher chances of worse quality of life than men. We concluded that with exception to the time of diagnosis and sex, other variables that influenced quality of life of diabetics were modifiable factors (glycated hemoglobin, alimentary diet and physical activity).

17α-methyltestosterone (17α-MT) is a hormone used in medicine and aquaculture which can be found in natural waters. It is considered an emerging organic pollutant and its accurate and precise analysis is required. Therefore, this study presents the in-house validation of a new voltammetric methodology for 17α-MT analysis in natural waters. A hanging mercury drop electrode and NaOH 5.0×10-3 mol L-1 solution as the electrolyte were employed in the voltammetric determinations. To confirm the presence of 17α-MT in water samples quantitative analysis was performed by ESI-MS/MS. The methodology exhibited good selectivity, linearity, accuracy (recovery of between 100.4 and 108.8%) and precision (RSDs for repeatability of 2.85% and for intermediate precision of 14.10%, with n = 5, respectively). LOD and LOQ were 3.07 µg L-1 and 10.78 µg L-1, respectively. The methodology was suitable for determination of 17α-MT in natural waters due to low-cost, good performance and no sample pre-treatment required.